5-甲氧基苯并[b]噻吩-2-羧酸甲酯合成路线 （共 6 条）
反应条件
sodium hydride 1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min; Yield given. Multistep reaction;
参考文献
MethylGene Inc.
Patent: US2010/279983 A1, 2010 ;
Location in patent: Page/Page column 22 ;
US 20100279983 A1
反应条件
palladium diacetate; potassium carbonate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran T=110°C; P=7757.43 Torr; 15 h; Autoclave;
参考文献
Zeng, Fanlong; Alper, Howard
Organic Letters, 2011 , vol. 13, # 11 p. 2868 - 2871
反应条件
potassium carbonate in acetonitrile T=20°C; Reflux; Product distribution / selectivity;
参考文献
LIFE TECHNOLOGIES CORPORATION; JUO, Rouh-Rong; BROOKS, Edward; GEE, Melissa; WANG, Zhixian H; SKAARE, Kathleen
Patent: WO2010/101839 A2, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 5-(methoxy)-1-benzothiophene-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Inert atmosphere; 2: methanol in dichloromethane T=20 - 40°C; Product distribution / selectivity;
参考文献
LIFE TECHNOLOGIES CORPORATION; JUO, Rouh-Rong; BROOKS, Edward; GEE, Melissa; WANG, Zhixian H; SKAARE, Kathleen
Patent: WO2010/101839 A2, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
1: 1.) n-BuLi, N,N,N',N'-tetramethylethylenediamine (TMEDA) / 1.) hexane, THF, -78 deg C, 2.) -78 deg C 2: 1.) NaH / 1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min View Scheme
参考文献
Bridges, Alexander J.; Lee, Arthur; Maduakor, Emmanuel C.; Eric Schwartz
Tetrahedron Letters, 1992 , vol. 33, # 49 p. 7499 - 7502
反应条件
1: With water; sodium hydroxide in tetrahydrofuran T=0 - 20°C; 2 h; 2: With hydrogenchloride in water; ethyl acetate pH=2;
参考文献
MethylGene Inc.
Patent: US2010/279983 A1, 2010 ;
Location in patent: Page/Page column 23 ;
US 20100279983 A1
