Ipr.HCl; palladium diacetate; potassium carbonate in 1-methyl-pyrrolidin-2-one T=150°C; 24 h; Inert atmosphereSealed tube;

(i) NBS, (PhCO)2O2, (ii) KMnO4, H2O; Multistep reaction;

pyridine T=270°C;

1: 2-chloro-2'-methylbiphenyl With sec.-butyllithium in diethyl ether; cyclohexane T=-78 - -45°C; Inert atmosphere; 2: chloro-dicyclohexylphosphine in diethyl ether; cyclohexane T=-78°C; Inert atmosphere;

1: With Zn[N(SiMe3)2]2; tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran Buchwald-Hartwig amination; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere;

pyridine T=270°C; Erwaermen des erhaltenen 2'-Methyl-biphenyl-carbonitrils-(2) mit Schwefelsaeure;

1.1: Zn[N(SiMe3)2]2; tri-tert-butyl phosphine; lithium chloride; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran / Inert atmosphere 1.2: Inert atmosphere 2.1: sodium azide; acetic acid; sodium nitrite / water / 0.5 h / 0 - 20 °C / Inert atmosphere 3.1: anhydrous xylene / 150 °C / Inert atmosphere; sealed tube View Scheme