(5As,7s)-7-异丙烯基-3-甲基-6,7,8,9-四氢-5ah-吡喃并[4,3-b]色烯-1-酮合成路线 （共 3 条）
反应条件
L-proline in ethyl acetate T=70°C; 24 h;
参考文献
Kansas State University Research Foundation
Patent: US6916824 B1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 2-N-Acetylguanine; (5aS,7S)-7-[(1R/S)-2-bromo-1-methylethyl]-3-methyl-1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyran With sodium hydride in N,N-dimethyl-formamide; mineral oil T=25°C; 0.5 h; Inert atmosphere; 2: (5aS,7S)-7-[(1R/S)-2-bromo-1-methylethyl]-3-methyl-1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyran in N,N-dimethyl-formamide; mineral oil T=25 - 60°C; 72 h; Inert atmosphere;
参考文献
Rana, Sandeep; Hong, Hyun-Seok; Barrigan, Lydia; Jin, Lee-Way; Hua, Duy H.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 670 - 674
反应条件
sodium hydride in N,N-dimethyl-formamide T=25 - 85°C; 24 h; Inert atmosphere;
参考文献
Rana, Sandeep; Hong, Hyun-Seok; Barrigan, Lydia; Jin, Lee-Way; Hua, Duy H.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 670 - 674
