3-(2-噻吩基)-1-丙醇合成路线 （共 5 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran T=0 - 20°C; 5 h; 2: With potassium carbonate in tetrahydrofuran; water T=0°C;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 87-88 ;
WO 2011/061214 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=20°C; 23 h;
参考文献
EP2168944 A1, ;
Page/Page column 104 ;
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=-78°C; 1 h;
参考文献
Carroll, F. Ivy; Melvin, Matt S.; Nuckols, Michel C.; Mascarella, S. Wayne; Navarro, Hernan A.; Thomas, James B.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1781 - 1791
反应条件
sodium tetrahydroborate in methanol Yield given;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 6 p. 1665 - 1668
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane
T=-78 - 20°C;
参考文献
Carroll, F. Ivy; Melvin, Matt S.; Nuckols, Michel C.; Mascarella, S. Wayne; Navarro, Hernan A.; Thomas, James B.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1781 - 1791
