N'-[5-[[4-[[5-(乙酰基羟基氨基)戊基]氨基]-1,4-二氧代丁基]羟基氨基]戊基]-N-(5-氨基戊基)-N-羟基琥珀酰胺单盐酸盐合成路线 （共 9 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
P=760 Torr; 7.5 h;
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 98 percent / pyridine / 1.5 h / 100 °C
2: 98 percent / DCC, DMAP / CHCl3 / 24.5 h / 0 - 20 °C
3: 82 percent / H2, NH3 / Raney Ni / methanol; H2O / 2.5 h / 2585.7 Torr
4: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
5: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 98 percent / DCC, DMAP / CHCl3 / 24.5 h / 0 - 20 °C
2: 82 percent / H2, NH3 / Raney Ni / methanol; H2O / 2.5 h / 2585.7 Torr
3: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
4: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 98 percent / DCC, DMAP / CHCl3 / 24.5 h / 0 - 20 °C
2: 82 percent / H2, NH3 / Raney Ni / methanol; H2O / 2.5 h / 2585.7 Torr
3: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
4: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 88 percent / H2, NH3 / Raney Ni / methanol; H2O / 3 h / 2585.7 Torr
2: 98 percent / DCC, DMAP / CHCl3 / 24.5 h / 0 - 20 °C
3: 82 percent / H2, NH3 / Raney Ni / methanol; H2O / 2.5 h / 2585.7 Torr
4: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
5: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
2: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
1: 82 percent / H2, NH3 / Raney Ni / methanol; H2O / 2.5 h / 2585.7 Torr
2: 88 percent / DCC, DMAP / CHCl3 / 12.2 h / 0 - 20 °C
3: 84 percent / H2, 0.1 N aq. HCl / 10percent Pd/C / methanol / 7.5 h / 760 Torr
View Scheme
参考文献
Bergeron, Raymond J.; Pegram, Joseph J.
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3131 - 3134
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
P=760 Torr; Product distribution;
参考文献
Bergeron; McManis; Phanstiel IV; Vinson
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 109 - 114
参考文献
Bickel,H. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 1385 - 1389
