3-(6-(二甲基氨基)-4-甲基吡啶-3-基)-2,5-二甲基-N,N-二丙基吡唑并[1,5-a]嘧啶-7-胺合成路线 （共 8 条）
反应条件
in acetonitrile 3 h; Heating;
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
反应条件
1.1: Br2; aq. Na2CO3 / CH2Cl2 / 0.5 h / 0 °C 2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h 2.2: 77 percent / tetrahydrofuran / 20 °C 3.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C 3.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C 4.1: 80 percent / NaH / tetrahydrofuran / 20 °C 5.1: 93 percent / hydrazine hydrobromide / ethanol; H2O / 1 h / Heating 6.1: 62 percent / dioxane / 20 h / Heating 7.1: 99 percent / POCl3 / acetonitrile / 8 h / Heating 8.1: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C 1.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C 2.1: 80 percent / NaH / tetrahydrofuran / 20 °C 3.1: 93 percent / hydrazine hydrobromide / ethanol; H2O / 1 h / Heating 4.1: 62 percent / dioxane / 20 h / Heating 5.1: 99 percent / POCl3 / acetonitrile / 8 h / Heating 6.1: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h 1.2: 77 percent / tetrahydrofuran / 20 °C 2.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C 2.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C 3.1: 80 percent / NaH / tetrahydrofuran / 20 °C 4.1: 93 percent / hydrazine hydrobromide / ethanol; H2O / 1 h / Heating 5.1: 62 percent / dioxane / 20 h / Heating 6.1: 99 percent / POCl3 / acetonitrile / 8 h / Heating 7.1: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1: 80 percent / NaH / tetrahydrofuran / 20 °C 2: 93 percent / hydrazine hydrobromide / ethanol; H2O / 1 h / Heating 3: 62 percent / dioxane / 20 h / Heating 4: 99 percent / POCl3 / acetonitrile / 8 h / Heating 5: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1: 93 percent / hydrazine hydrobromide / ethanol; H2O / 1 h / Heating 2: 62 percent / dioxane / 20 h / Heating 3: 99 percent / POCl3 / acetonitrile / 8 h / Heating 4: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1: 62 percent / dioxane / 20 h / Heating 2: 99 percent / POCl3 / acetonitrile / 8 h / Heating 3: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1: 99 percent / POCl3 / acetonitrile / 8 h / Heating 2: 72 percent / acetonitrile / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
