4-(3-氨基丙基)-2,6-二-叔丁基苯酚合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in diethyl ether Reduction; 5.5 h; Heating;
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
反应条件
1: 98 percent / H2 / Pd/C / ethanol / 3 h / 20 °C / 2585.81 Torr 2: thionyl chloride; DMF / toluene; CH2Cl2 / 2 h / 20 °C 3: 28.6 g / NH4OH / tetrahydrofuran / 0.25 h / 0 °C 4: 45 percent / LiAlH4 / diethyl ether / 5.5 h / Heating View Scheme
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
反应条件
1: thionyl chloride; DMF / toluene; CH2Cl2 / 2 h / 20 °C 2: 28.6 g / NH4OH / tetrahydrofuran / 0.25 h / 0 °C 3: 45 percent / LiAlH4 / diethyl ether / 5.5 h / Heating View Scheme
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
反应条件
triethylamine in acetonitrile T=18 - 45°C;
参考文献
Furin; Krysin; Protsuk; Lopyrev
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 10 p. 1429 - 1434
反应条件
hydrogen; platinum(IV) oxide in ethanol; water
T=60°C; P=2206.5 Torr;
参考文献
E.Merck AG
Patent: BE633799 , 1963 ;
Chem.Abstr., 1964 , vol. 61, # 4264
