2-氟-1,3-二甲氧基苯合成路线 （共 6 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.25 h; 2: With hypophosphorous ether in water T=4 - 20°C;
参考文献
Chan, Jefferson; Lu, April; Bennet, Andrew J.
Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 2989 - 2997
反应条件
1: 99 percent / methanol / Ambient temperature 2: 92 percent / H2 / Pd/C / ethanol; ethyl acetate / 2068.6 Torr 3: 1.) NaNO2, HCl, 2.) H3PO2 / 1.) H2O, 15 min, 2.) H2O, 4 deg C, overnight, 20 deg C, 2 h View Scheme
参考文献
Chan, Jefferson; Lu, April; Bennet, Andrew J.
Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 2989 - 2997
反应条件
1: 92 percent / H2 / Pd/C / ethanol; ethyl acetate / 2068.6 Torr 2: 1.) NaNO2, HCl, 2.) H3PO2 / 1.) H2O, 15 min, 2.) H2O, 4 deg C, overnight, 20 deg C, 2 h View Scheme
参考文献
Chan, Jefferson; Lu, April; Bennet, Andrew J.
Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 2989 - 2997
反应条件
potassium carbonate in acetone 3 h; Heating;
参考文献
Dodean, Rozalia A.; Kelly, Jane X.; Peyton, David; Gard, Gary L.; Riscoe, Michael K.; Winter, Rolf W.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1174 - 1183
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) T=70°C; 3 h; Ionic liquid;
参考文献
Pavlinac, Jasminka; Zupan, Marko; Stavber, Stojan
Molecules, 2009 , vol. 14, # 7 p. 2394 - 2409
反应条件
boron tribromide in dichloromethane
参考文献
Sun, Wei-Chuan; Gee, Kyle R.; Klaubert, Dieter H.; Haugland, Richard P.
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6469 - 6475
