3-羟基-5-甲氧基苯甲酸合成路线 （共 13 条）
反应条件
sodium hydroxide in methanol T=45°C; Inert atmosphere;
参考文献
Koolaji, Nooshin; Abu-Mellal, Abdallah; Tran, Van H.; Duke, Rujee K.; Duke, Colin C.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 415 - 422
反应条件
1: 39 percent / NaH / dimethylformamide 2: 13 percent / aq. KOH / methanol View Scheme
参考文献
Koolaji, Nooshin; Abu-Mellal, Abdallah; Tran, Van H.; Duke, Rujee K.; Duke, Colin C.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 415 - 422
反应条件
sulfuric acid in chloroform
参考文献
Laatsch; Anke
1982 , vol. No. 12, p. 2189 - 2215
反应条件
1: acetyl chloride / 17 h / |Reflux; |Inert atmosphere 2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2.33 h / 0 - 20 °C / |Inert atmosphere 3: sodium hydroxide / methanol / 45 °C / |Inert atmosphere View Scheme
参考文献
Koolaji, Nooshin; Abu-Mellal, Abdallah; Tran, Van H.; Duke, Rujee K.; Duke, Colin C.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 415 - 422
反应条件
sodium methylate Behandeln des Reaktionsprodukts mit wss. Kalilauge;
参考文献
Bonjean; Schunack
Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 4 p. 501 - 507
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
参考文献
Calam et al.
Biochemical Journal, 1939 , vol. 33, p. 579,585
Biochemical Journal, 1947 , vol. 41, p. 458,460
参考文献
Occelli, Emilio; DePaoli, Adele; Nathansohn, Giangiacomo
Gazzetta Chimica Italiana, 1981 , vol. 111, # 9/10 p. 383 - 390
反应条件
in diethyl ether; acetone
0.0166667 h;
参考文献
Laatsch; Anke
1982 , vol. No. 12, p. 2189 - 2215
反应条件
1: potassium carbonate / acetone
2: diethyl ether
View Scheme
参考文献
Cannon,J.R. et al.
Australian Journal of Chemistry, 1973 , vol. 26, p. 2257 - 2275
