(R/s)-2-(3,4,5-三甲氧基苯基)丁酸合成路线 （共 3 条）
反应条件
hydrogenchloride; sodium hexamethyldisilazane in tetrahydrofuran; hexane; ethyl acetate
参考文献
Ariad Gene Therapeutics, Inc.
Patent: US6566073 B1, 2003 ;
反应条件
1: 3,4,5-trimethoxy-phenyl-acetic acid With sodium hexamethyldisilazane in tetrahydrofuran T=0°C; Methylation; 0.25 h; 2: EtBr(-I) in tetrahydrofuran T=20°C; Alkylation; 12 h; Further stages.;
参考文献
Yang, Wu; Rozamus, Leonard W.; Narula, Surinder; Rollins, Carl T.; Yuan, Ruth; Andrade, Lawrence J.; Ram, Mary K.; Phillips, Thomas B.; Van Schravendijk, Marie Rose; Dalgarno, David; Clackson, Tim; Holt, Dennis A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 6 p. 1135 - 1142
反应条件
1: With cinchonidine in acetonitrile Separation of racemate; 2: With hydrogenchloride in dichloromethane; water pH=2; Separation of racemate;
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
Location in patent: Page/Page column 11-12 ;
