D-4-(羧基氨基)-戊酰胺酸4-苄酯合成路线 （共 6 条）
反应条件
1: H2 / Pd/C / H2O / 8 h / 20 °C / 2250.18 - 3000.24 Torr 2: 15.35 g / NaHCO3 / acetone / 72 h / 20 °C View Scheme
参考文献
Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122
反应条件
hydrogen; palladium on activated charcoal
参考文献
Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122
反应条件
1: With dicyclohexyl-carbodiimide in tetrahydrofuran
7 h; cooling;
2: With ammonia in tetrahydrofuran
0.5 h; cooling;
参考文献
Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122
反应条件
1.1: 96 percent / aq. NaOH / 0.25 h / 60 °C
2.1: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 7 h / cooling
2.2: 52.5 percent / NH3(gas) / tetrahydrofuran / 0.5 h / cooling
View Scheme
参考文献
Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122
反应条件
1.1: 96 percent / aq. NaOH / 0.25 h / 60 °C
2.1: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 7 h / cooling
2.2: 52.5 percent / NH3(gas) / tetrahydrofuran / 0.5 h / cooling
View Scheme
参考文献
Yang, Hong-Zhen; Xu, Song; Liao, Xue-Yan; Zhang, Suo-De; Liang, Zheng-Lun; Liu, Bai-He; Bai, Jin-Ye; Jiang, Chao; Ding, Jian; Cheng, Gui-Fang; Liu, Gang
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5112 - 5122
参考文献
Shealy; Opliger; Montgomery
Journal of pharmaceutical sciences, 1968 , vol. 57, # 5 p. 757 - 764
