D-谷氨酸的α-酰胺盐酸盐合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal
参考文献
Journal of pharmaceutical sciences, , vol. 57, # 5 p. 757 - 764
参考文献
Wu, Shin-Hsiung; Chu, Fei-Ya; Chang, Chung-Ho; Wang, Kung-Tsung
Tetrahedron Letters, 1991 , vol. 32, # 29 p. 3529 - 3530
反应条件
1.1: 96 percent / aq. NaOH / 0.25 h / 60 °C 2.1: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 7 h / cooling 2.2: 52.5 percent / NH3(gas) / tetrahydrofuran / 0.5 h / cooling 3.1: H2 / Pd/C / H2O / 8 h / 20 °C / 2250.18 - 3000.24 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5112 - 5122
反应条件
1.1: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 7 h / cooling 1.2: 52.5 percent / NH3(gas) / tetrahydrofuran / 0.5 h / cooling 2.1: H2 / Pd/C / H2O / 8 h / 20 °C / 2250.18 - 3000.24 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 16 p. 5112 - 5122
反应条件
1: acetic acid / 5 percent Pd/C / 72 h 2: 50 percent TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 12 p. 1361 - 1363
反应条件
2: DCC / tetrahydrofuran 3: 25 percent aq. NH4OH 4: acetic acid / 5 percent Pd/C / 72 h 5: 50 percent TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 12 p. 1361 - 1363
反应条件
1: DCC / tetrahydrofuran 2: 25 percent aq. NH4OH 3: acetic acid / 5 percent Pd/C / 72 h 4: 50 percent TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 12 p. 1361 - 1363
反应条件
1: 25 percent aq. NH4OH 2: acetic acid / 5 percent Pd/C / 72 h 3: 50 percent TFA / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 12 p. 1361 - 1363
反应条件
hydrogenchloride; acetic acid
参考文献
Bulletin de la Societe chimique de France, , vol. 10, p. 3561 - 3566
反应条件
1: 90 percent / enzymatically with Candida cylindracea lipase 2: 85 percent / NH3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 29 p. 3529 - 3530
