1-溴-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯合成路线 （共 4 条）
195324-88-01-溴-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯
→
反应条件
1.1: t-BuLi / diethyl ether; pentane / 1 h / -40 °C 1.2: diethyl ether; pentane / -40 - 20 °C 2.1: 0.88 g / alane-N,N-dimethylamine / toluene / 3 h / 90 °C View Scheme
参考文献
Dandapani, Sivaraman; Curran, Dennis P.
Tetrahedron, 2002 , vol. 58, # 20 p. 3855 - 3864
195324-88-01-溴-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯
→
反应条件
1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -40 °C 2: 2.70 g / NaBH4 / ethanol / 16 h / 25 °C View Scheme
参考文献
Li, Yu; Guo, Qi; Li, Xuefei; Zhang, Hua; Yu, Fanghua; Yu, Weijiang; Xia, Guiquan; Fu, Mingyang; Yang, Zhigang; Jiang, Zhong-Xing
Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2110 - 2113
2043-53-01,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-十七氟-10-碘庚烷+
→
195324-88-01-溴-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯
反应条件
1: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-iododecane With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran
T=20°C; 15 h;
2: 4-bromo-1-iodobenzene in tetrahydrofuran
T=45°C; 12 h;
参考文献
Curran, Dennis P.; Oderaotoshi, Yoji
Tetrahedron, 2001 , vol. 57, # 24 p. 5243 - 5253
2043-53-01,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-十七氟-10-碘庚烷+
→
195324-88-01-溴-4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯
反应条件
1: p-bromophenyl bromide With magnesium in tetrahydrofuran
T=20°C; 24 h;
2: 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-iododecane With di-.mu.-chloro-bis(1,5-cyclooctadiene)dicopper in tetrahydrofuran; diethyl ether
T=-5 - 20°C;
参考文献
Schneider, Siegfried; Bannwarth, Willi
Angewandte Chemie, International Edition, 2000 , vol. 39, # 22 p. 4142 - 4145
Angewandte Chemie, 2000 , vol. 112, p. 4293 - 4296
