3-(叔丁氧基羰基)-2,2-二甲基丙酸甲酯合成路线 （共 5 条）
反应条件
1: N-(tert-butoxycarbonyl)-β-alanine methyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=-78°C; 0.5 h;
参考文献
McCubbin, J. Adam; Maddess, Matthew L.; Lautens, Mark
Organic Letters, 2006 , vol. 8, # 14 p. 2993 - 2996
反应条件
1: With sodium tetrahydroborate; nickel dichloride in methanol T=0 - 20°C; 17 h; 2: With N1-(2-Amino-ethyl)-ethane-1,2-diamine in methanol 0.5 h;
参考文献
FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.
Patent: WO2013/134660 A1, 2013 ;
Location in patent: Paragraph 0429 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.25 h;
参考文献
Seebach, Dieter; Abele, Stefan; Sifferlen, Thierry; Haenggi, Martin; Gruner, Sibylle; Seiler, Paul
Helvetica Chimica Acta, 1998 , vol. 81, # 12 p. 2218 - 2243
反应条件
sodium hydroxide in methanol; water T=20°C; 24 h;
参考文献
McCubbin, J. Adam; Maddess, Matthew L.; Lautens, Mark
Organic Letters, 2006 , vol. 8, # 14 p. 2993 - 2996
反应条件
sodium hydroxide in methanol; water T=20°C; 16 h;
参考文献
FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.
Patent: WO2013/134660 A1, 2013 ;
Location in patent: Paragraph 0430 ;
