呋喃[2,3-c]并吡啶合成路线 （共 28 条）
反应条件
1: 1.) n-BuLi, i-Pr2EtN / 1.) THF, hexane, from -70 deg C to -30 deg C, 2.) THF, hexane, from -70 deg C to RT 2: AcOH / ethanol / Ambient temperature 3: NaCNBH3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
ammonia; sodium in diethyl ether Birch reduction; 0.5 h;
参考文献
Yamaguchi, Seiji; Hamade, Eriko; Yokoyama, Hajime; Hirai, Yoshiro; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 2 p. 335 - 339
反应条件
1: With n-butyllithium; LiDMAE in toluene T=-78°C; 1 h; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran T=-78°C; 1 h; 3: With water regioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 7 p. 2227 - 2235
反应条件
1: 41 percent / sulfuric acid, fuming nitric acid (d,1.50); / 1.5 h 2: 80 percent / 10percent HCl / 16 h / Heating View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki; Inoue, Masatoshi; Ishida, Toshimasa; Iitaka, Yoichi; Itai, Akiko
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 725 - 736
反应条件
2: 98 percent / hydroxylamine hydrochloride, K2CO3 / aq. ethanol / 2 h / Ambient temperature
3: 73 percent / p-toluenesulfonic acid, acetic anhydride / 5 h / Heating
4: 95 percent / KOH / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Morita, Hiroyuki; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 373 - 376
反应条件
ammonia; sodium in diethyl ether
Birch reduction; 0.5 h;
参考文献
Yamaguchi, Seiji; Hamade, Eriko; Yokoyama, Hajime; Hirai, Yoshiro; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 2 p. 335 - 339
反应条件
2: 95 percent / hydrazine hydrate, KOH / ethanol / 1 h / Heating
View Scheme
参考文献
Morita, Hiroyuki; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 373 - 376
反应条件
bromine in chloroform
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki; Inoue, Masatoshi; Ishida, Toshimasa; Iitaka, Yoichi; Itai, Akiko
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 725 - 736
