5-氨基-3-(4-甲氧基苯基)-1H-吡唑合成路线 （共 7 条）
反应条件
hydrazine in ethanol T=80°C; 15 h;
参考文献
STRUCTURAL GENOMIX, INC.
Patent: WO2005/68473 A1, 2005 ;
Location in patent: Page/Page column 49-50 ;
WO 2005/068473 A1
反应条件
1: With hydrazine in acetic acid T=96 - 98°C; 5.5 h; 2: With hydrogenchloride in water; acetic acid 6 h; Heating / reflux; 3: With ammonia in water; acetic acid pH=8 - 9;
参考文献
WO2007/17678 A1, ;
Page/Page column 34; 37-38 ;
反应条件
hydrazine hydrate in ethanol 5 h; Heating;
参考文献
Hartmann, Horst; Liebscher, Juergen
Synthesis, 1984 , # 3 p. 276 - 277
反应条件
hydrazine hydrate in ethanol 4 h; Heating;
参考文献
Nenaidenko; Golubinskii; Lenkova; Shastin; Balenkova
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 10 p. 1518 - 1520
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / -78 - 20 °C 2.1: hydrazine monohydrate / ethanol / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 22 p. 7501 - 7511
反应条件
1.1: dihydrogen peroxide; acetic acid / dichloromethane / 5 h / 45 °C 2.1: hydrazine hydrate / ethanol / 2.33 h / -5 °C / Reflux 2.2: 1 h / 55 °C View Scheme
参考文献
Heterocyclic Communications, , vol. 17, # 3-4 p. 139 - 145
反应条件
1: With sodium ethanolate in ethanol
T=150°C; 1.66667 h; microwave irradiation;
2: With trichlorophosphate
5 h; Cooling with iceReflux;
参考文献
AJINOMOTO CO., INC.
Patent: US2011/294781 A1, 2011 ;
Location in patent: Page/Page column 25 ;
