1-Boc-3,3-二氟吡咯烷合成路线 （共 3 条）
反应条件
diethylamino-sulfur trifluoride in benzene T=0 - 20°C; 72 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 62 ;
反应条件
hydrogenchloride in diethyl ether; ethyl acetate T=20°C; 3 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 49 ;
WO 2004/069256 A1
反应条件
hydrogenchloride in 1,4-dioxane T=0 - 20°C; 1.66667 h;
参考文献
O'Connor, Stephen P.; Lawrence, Michael; Shi, Yan; Stein, Philip D.
Patent: US2004/186134 A1, 2004 ;
Location in patent: Page 241 ;
