3-三氟甲基联苯-4-羧酸合成路线 （共 2 条）
反应条件
1: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate in 1,4-dioxane; ethanol T=80°C; 2 h; 2: With hydrogenchloride in water; ethyl acetate
参考文献
Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E.
Patent: US2013/102584 A1, 2013 ;
Location in patent: Paragraph 0307; 0308 ;
反应条件
1: With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=95°C; Suzuki Coupling; 2 h; 2: With hydrogenchloride in ethylene glycol dimethyl ether; water pH=1 - 2;
参考文献
US2006/183754 A1, ;
Page/Page column 25 ;
