4’-三氟甲基-二苯基-4-甲酸合成路线 （共 7 条）
反应条件
ethylenediaminetetraacetic acid; potassium carbonate; palladium dichloride T=100°C; Suzuki-Miyaura reaction; 0.25 h;
参考文献
Tetrahedron Letters, , vol. 46, # 34 p. 5751 - 5754
反应条件
potassium fluoride; potassium carbonate in water T=100°C; Suzuki-Miyaura coupling; 2 h;
参考文献
Green Chemistry, , vol. 12, # 1 p. 150 - 158
反应条件
1: With palladium diacetate; sodium carbonate; triphenylphosphine in water; acetone 5 h; RefluxInert atmosphere; 2: With hydrogenchloride in water; acetone T=20°C;
参考文献
Journal of Organic Chemistry, , vol. 74, # 15 p. 5163 - 5173
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C;
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C 1.2: 46 percent / tetrahydrofuran; hexane / 4 h / -78 - 20 °C 2.1: 65 percent / CuF2*2H2O / diethyl ether / 20 °C 3.1: TBAF / Pd(PPh3)4 / tetrahydrofuran / 80 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
1: 65 percent / CuF2*2H2O / diethyl ether / 20 °C 2: TBAF / Pd(PPh3)4 / tetrahydrofuran / 80 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
WO2013/78430 A1, ;
Paragraph 0353 ;
