5-硝基间苯二甲酸单甲酯合成路线 （共 12 条）
反应条件
sulfuric acid in tetrahydrofuran T=65°C;
参考文献
Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
反应条件
thionyl chloride 6 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BIOLIPOX AB
Patent: WO2008/71944 A1, 2008 ;
Location in patent: Page/Page column 56; 62 ;
反应条件
thionyl chloride in toluene
参考文献
AstraZeneca UK Limited
Patent: US6200981 B1, 2001 ;
US 6200981 B1
反应条件
1: SO2(NH2)2; SOCl2 / tetrahydrothiophene 1,1-dioxide / 42 h / Heating 2: H2 / Pd/C / methanol View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
hydrogen; palladium dihydroxide in methanol P=2585.81 Torr; 5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/15166 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/015166 A1
反应条件
thionyl chloride; amidosulfamic acid in sulfolane 42 h; Heating;
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
pyridine; hydrogenchloride; lithium tri(t-butoxy)aluminum hydride in tetrahydrofuran; N-methyl-acetamide; hexane; dichloromethane; ethyl acetate; acetonitrile
参考文献
BioCryst Pharmaceuticals, Inc.
Patent: US5602277 A1, 1997 ;
反应条件
1: 70 percent / BH3*THF / tetrahydrofuran / -10 - 64 °C 2: 78 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.75 h / -78 °C View Scheme
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
反应条件
1.1: 1 g / H2 / Pd/C / methanol 2.1: NaNO2; aq. HBr / cooling 2.2: 95 percent / CuBr; aq. HBr / 1.5 h / 0 - 70 °C View Scheme
参考文献
Choi, Kihang; Hamilton, Andrew D.
Journal of the American Chemical Society, 2003 , vol. 125, # 34 p. 10241 - 10249
反应条件
hydrogenchloride; ammonium hydroxide
参考文献
Schering Aktiengesellschaft
Patent: EP1186305 A1, 2002 ;
