6,7-二甲基-1-四醛酮合成路线 （共 14 条）
反应条件
AlCl3, aluminium chloride in chloroform T=20°C; 2 h;
参考文献
Taisho Pharmaceutical Co. Ltd.
Patent: EP1650202 A1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
sulfuric acid T=100°C; 2 h;
参考文献
Boberg, Friedrich; Jachiewicz, Adam; Garming, Alfons
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 72, # 1-4 p. 1 - 12
反应条件
(i) N2H4, KOH, HOCH2CH2OH, (ii) polyphosphoric acid; Multistep reaction;
参考文献
Barnett; Sanders
Journal of the Chemical Society, 1933 , p. 434,436
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5716944 A1, 1998 ;
反应条件
aluminium trichloride T=70°C; 6 h; Further byproducts given;
参考文献
Kadam; Desai; Mane
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 10 p. 752 - 756
反应条件
1: 86 percent / AlCl3 / CH2Cl2 2: 88 percent / 80percent N2H4*H2O, KOH / various solvent(s) / 1) 2 h, reflux, 2) 180-190 deg C, ca. 4 h 3: 74 percent / 80percent H2SO4 / 2 h / 100 °C View Scheme
参考文献
Barnett; Sanders
Journal of the Chemical Society, 1933 , p. 434,436
反应条件
2,6-dichloro-benzonitrile; bromine 1.)CH2Cl2, 0 deg C, 2.) 23 deg C; Multistep reaction;
参考文献
Corey, E. J.; Estreicher, Herbert
Tetrahedron Letters, 1981 , vol. 22, p. 603 - 606
反应条件
(i), (ii) sulfur; Multistep reaction;
参考文献
Dozen,Y.
Bulletin of the Chemical Society of Japan, 1972 , vol. 45, p. 519 - 525
参考文献
Falk,H. et al.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 907 - 919
反应条件
2: KHSO4
View Scheme
参考文献
Falk,H. et al.
Monatshefte fuer Chemie, 1976 , vol. 107, p. 907 - 919
