3,5-双乙酰基-5-碘代-2-脱氧尿苷合成路线 （共 13 条）
反应条件
ammonium cerium (IV) nitrate; [MoeMim][Ms]; lithium iodide T=80°C; 0.333333 h;
参考文献
Kumar, Vineet; Malhotra, Sanjay V.
Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 9 p. 821 - 834
反应条件
pyridine T=20°C; 16.5 h;
参考文献
Durand, Adeline; Brown, Tom
Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 6-7 p. 785 - 794
反应条件
KIO3; iodine; sulfuric acid in water; acetonitrile T=55°C; 2 h;
参考文献
Kumar; Knaus; Wiebe
Journal of Heterocyclic Chemistry, 1992 , vol. 28, # 8 p. 1917 - 1925
反应条件
HClO4; acetic anhydride in acetic acid
参考文献
Nycomed Amersham PLC
Patent: US6444682 B1, 2002 ;
反应条件
acetic anhydride; acetic acid 1.) 0 deg C, 1 h, 2.) RT, 24 h;
参考文献
Lin; Gao
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 598 - 601
反应条件
1: 94 percent / pyridine / 24 h / 4 °C 2: 1.) mercuric acetate, 0.5 M NaOAc; 2.) I2 / 1.) EtOH, 50 deg C, overnight, 2.) EtOH, 90 min View Scheme
参考文献
Chen, Miaojuan; Qu, Dezhong; Chi, Weilin; Wang, Wei; Ren, Xiaoshuai; Cong, Shujie; Liang, Peizhou; Feng, Shipeng; Zhang, Biliang
Science China Chemistry, 2011 , vol. 54, # 11 p. 1702 - 1710
反应条件
sodium methylate in methanol 1 h; Ambient temperature;
参考文献
Asakura, Jun-ichi; Robins, Morris J.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933
反应条件
1: tetrabutyl ammonium fluoride; tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran; N,N-dimethyl-formamide; water / 1 h / 100 °C / |Inert atmosphere 2: ammonia / methanol View Scheme
参考文献
Liang, Yong; Gloudeman, Jennifer; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4094 - 4103
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / dichloromethane / 20 h 2: ammonia; water / 2 h 3: methanol; potassium carbonate View Scheme
参考文献
Science China Chemistry, , vol. 54, # 11 p. 1702 - 1710
反应条件
1: 68 percent / Et3N / (Ph3P)2PdCl2, CuI / 3 h / 50 °C 2: H2, quinoline / Lindlar catalyst / ethyl acetate / 5 h / 25 °C / 760 Torr 3: 40 percent / 1.) Br2, 2.) NH3/MeOH / 1.) CS2, 35 min, -100 deg C, 2.) MeCN, 18 h, 25 deg C View Scheme
参考文献
Robins, Morris J.; Barr, Philip J.
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1854 - 1862
