1-(3,4-二甲氧基苯基)-2-丙醇合成路线 （共 14 条）
反应条件
zirconium(IV) hydrous oxide hydroxide; isopropyl alcohol T=130°C; Meerwein-Ponndorf-Verley Reduction; 0.666667 h;
参考文献
Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V.
Organic Letters, 2013 , vol. 15, # 9 p. 2278 - 2281
反应条件
1: With trimethylsilyl trifluoromethanesulfonate; benzo[1,3,2]dioxaborole; [Rh(acac)(COD)]2; (R)-1-(2-phenylquinazolin-4-yl)-2-(Ph2P)-naphthalene in tetrahydrofuran T=25°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; Oxidation; Hydrolysis; 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
反应条件
1: With CF3O3S(1-)*C45H39N2OPRh(1+); benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With dihydrogen peroxide; sodium hydroxide in ethanol; water T=0 - 20°C; optical yield given as percent eeenantioselective reaction;
参考文献
Maxwell, Aoife C.; Flanagan, Susan P.; Goddard, Richard; Guiry, Patrick J.
Tetrahedron Asymmetry, 2010 , vol. 21, # 11-12 p. 1458 - 1473
反应条件
sulfuric acid T=5°C;
参考文献
Manitto,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
反应条件
1: Fe, FeCl3, aq. HCl 2: LiAlH4 / diethyl ether View Scheme
参考文献
Morgan,P.H.; Beckett,A.H.
Tetrahedron, 1975 , vol. 31, p. 2595 - 2601
反应条件
1: NH4OAc / acetic acid 2: Fe, FeCl3, aq. HCl 3: LiAlH4 / diethyl ether View Scheme
参考文献
Morgan,P.H.; Beckett,A.H.
Tetrahedron, 1975 , vol. 31, p. 2595 - 2601
反应条件
(i) Hg(OAc)2, HBF4, (ii) KOH, EtOH; Multistep reaction;
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1972 , p. 4145 - 4148
反应条件
chromium(VI) oxide; sulfuric acid
参考文献
Manitto,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
反应条件
1: dihydrogen peroxide; NH4Br / acetic acid / 4 h / 20 °C 2: pyridine / 20 h / 20 °C 3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 24 h / 20 °C / |Inert atmosphere 4: copper(I) bromide / N,N-dimethyl-formamide / 18 h / |Reflux View Scheme
参考文献
Cabrera, Elvia V.; Marrugo, Kelly P.; Ortega, Jose G.; Banerjee, Ajoy K.; Sanchez, Jennifer L.
Organic Preparations and Procedures International, 2012 , vol. 44, # 5 p. 455 - 459,5
Title/Abstract Full Text Show Details
Cabrera, Elvia V.; Marrugo, Kelly P.; Ortega, Jose G.; Banerjee, Ajoy K.; Sanchez, Jennifer L.
Organic Preparations and Procedures International, 2012 , vol. 44, # 5 p. 455 - 459
反应条件
1: CrO3, H2SO4 2: (i) MCPBA, (ii) aq. KOH View Scheme
参考文献
Manitto,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
