1: 2-methoxybromobenzene With magnesium in tetrahydrofuran T=25°C; Metallation; 2: 2,6-Dibromopyridine With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran T=25°C; Substitution; 12 h; Further stages.;
参考文献
Li; Liu; Bu; Guo; Wang
Chemical Communications, 2000 , # 16 p. 1551 - 1552
1: 1-(2-methoxyphenyl)ethanone With potassium tert-butylate in tetrahydrofuran T=20°C; Metallation; 2 h; 2: (2E)-3-(dimethylamino)-1-(2-methoxyphenyl)-2-propen-1-one in tetrahydrofuran T=20°C; Addition; 3: With ammonium acetate; acetic acid in tetrahydrofuran Cyclization; 2 h;
参考文献
Silva, Artur M. S.; Almeida, Lucia M. P. M.; Cavaleiro, Jose A. S.; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.; Fontenas, Christophe; Jagerovic, Nadine; Elguero, Jose
Tetrahedron, 1997 , vol. 53, # 34 p. 11645 - 11658
1.1: 63 percent / 18 h / 110 °C 2.1: potassium tert-butoxide / tetrahydrofuran / 2 h / 20 °C 2.2: tetrahydrofuran / 20 °C 2.3: 60 percent / ammonium acetate; acetic acid / tetrahydrofuran / 2 h View Scheme
参考文献
Silva, Artur M. S.; Almeida, Lucia M. P. M.; Cavaleiro, Jose A. S.; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.; Fontenas, Christophe; Jagerovic, Nadine; Elguero, Jose
Tetrahedron, 1997 , vol. 53, # 34 p. 11645 - 11658
