4-氯-2,6-二酰基吡啶合成路线 （共 8 条）
反应条件
1: in tetrahydrofuran T=0 - 20°C; 2 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C;
参考文献
Ivchenko, Pavel V.; Nifant'Ev, Ilya E.; Buslov, Ivan V.
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 217 - 219
反应条件
hydrogen iodide in dichloromethane Substitution; 48 h;
参考文献
Dumont, Arnaud; Jacques, Vincent; Desreux, Jean F.
Tetrahedron, 2000 , vol. 56, # 14 p. 2043 - 2052
反应条件
1: 4-chloro pyridine hydrochloride With sodium carbonate in water Inert atmosphere; 2: 2-oxo-propionic acid With (NH4)2S2O8; sulfuric acid; silver nitrate in water T=20°C; 24 h; Inert atmosphere;
参考文献
Lieb, Dominik; Kenkell, Isabell; Miljkovic, Jan Lj.; Moldenhauer, Daniel; Weber, Nadine; Filipovic, Milos R.; Groehn, Franziska; Ivanovic-Burmazovic, Ivana
Inorganic Chemistry, 2014 , vol. 53, # 2 p. 1009 - 1020
反应条件
1: 68 percent / diethyl ether / 1 h / 0 °C 2: 99 percent / aq. HI / CH2Cl2 / 48 h View Scheme
参考文献
Tetrahedron, , vol. 56, # 14 p. 2043 - 2052
反应条件
1: 86 percent / SOCl2 / dimethylformamide / 2 h / Heating 2: 68 percent / diethyl ether / 1 h / 0 °C 3: 99 percent / aq. HI / CH2Cl2 / 48 h View Scheme
参考文献
Tetrahedron, , vol. 56, # 14 p. 2043 - 2052
反应条件
1: phosphorus pentachloride / chloroform / Inert atmosphere 2: sodium ethanolate / Inert atmosphere; Reflux 3: hydrogenchloride; water / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 9 p. 2054 - 2058
反应条件
1: sodium ethanolate / Inert atmosphere; Reflux 2: hydrogenchloride; water / Inert atmosphere; Reflux View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 9 p. 2054 - 2058
反应条件
acetic acid Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2263 - 2264
