1: 1-bromo-2-(methylthio)benzene With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=20°C; Cooling; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=20°C; Cooling with ice;
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP946508 B1, 2009 ;
Location in patent: Page/Page column 60 ;
1: With n-butyllithium in diethyl ether; hexane T=0°C; 1 h; 2: With boric acid trimethyl ester in diethyl ether; hexane T=-78 - 20°C; 3: With hydrogenchloride in diethyl ether; hexane; water
参考文献
Wade, Casey R.; Zhao, Haiyan; Gabbai, Franois P.
Chemical Communications, 2010 , vol. 46, # 34 p. 6380 - 6381
