4-甲氧基-[1,1-联苯]-3-羧酸甲酯合成路线 （共 13 条）
反应条件
sodium hydroxide in methanol; water 2 h; Reflux;
参考文献
Dai, Jun; Zhou, Kaifeng; Li, Ming; Sun, Huiqin; Chen, Yunqing; Su, Shijian; Pu, Xuemei; Huang, Yan; Lu, Zhiyun
Dalton Transactions, 2013 , vol. 42, # 29 p. 10559 - 10571
反应条件
sodium salt of phosphorous acid; palladium on activated charcoal in water; isopropyl alcohol
T=20°C; Suzuki-Miyaura cross-coupling; 36 h;
参考文献
Kitamura, Yoshiaki; Sakurai, Ai; Udzu, Takahiro; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2007 , vol. 63, # 43 p. 10596 - 10602
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 4 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate in 1,4-dioxane
T=80°C; Hiyama coupling; 1.5 h; Inert atmosphere;
参考文献
Raders, Steven M.; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1744 - 1747
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.25 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
tetrakis(triphenylphosphine) palladium(0); K3PO4*3H2O in 1,4-dioxane
T=90°C; 7 h; Inert atmosphere;
参考文献
Dai, Jun; Zhou, Kaifeng; Li, Ming; Sun, Huiqin; Chen, Yunqing; Su, Shijian; Pu, Xuemei; Huang, Yan; Lu, Zhiyun
Dalton Transactions, 2013 , vol. 42, # 29 p. 10559 - 10571
反应条件
1: C15H13O3Pol With trifluoroacetic acid in dichloromethane
T=20°C; 0.833333 h; Wang resin;
2: diazomethane
参考文献
Traficante, Carla I.; Delpiccolo, Carina M. L.; Mata, Ernesto G.
ACS Combinatorial Science, 2014 , vol. 16, # 5 p. 211 - 214
反应条件
1: CsF; Pd(OAc)2 / H2O / 22 h / 80 °C
2: ammonia / 20 °C
View Scheme
参考文献
Miao, Weishi; Chan, Tak Hang
Organic Letters, 2003 , vol. 5, # 26 p. 5003 - 5005
参考文献
Miao, Weishi; Chan, Tak Hang
Organic Letters, 2003 , vol. 5, # 26 p. 5003 - 5005
