4-甲氧基-[1,1-联苯]-3-羧酸甲酯合成路线 （共 13 条）
反应条件
1: 4-MeOC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: (3-bromophenyl)acetic acid methyl ester With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); tricyclo[3.3.1.13,7 ]-decane-1-carboxylic acid; potassium carbonate; silver carbonate in toluene
T=80°C; 40 h; Microwave irradiation;
2: With acetic acid in toluene
T=20°C; 0.0833333 h;
3: With manganese(IV) oxide in toluene
T=20°C; 0.5 h;
参考文献
Ricci, Paolo; Kraemer, Katrina; Cambeiro, Xacobe C.; Larrosa, Igor
Journal of the American Chemical Society, 2013 , vol. 135, # 36 p. 13258 - 13261
反应条件
1.1: sodium hydride / ethylene glycol dimethyl ether / 0.17 h / 0 - 20 °C / Inert atmosphere
1.2: 12 h / 0 - 20 °C / Inert atmosphere
2.1: potassium phosphate; bis(1,5-cyclooctadiene)nickel (0); tri-cyclo-hexyl-phosphine / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
