1: 1-methylguanidine hydrochloride With potassium tert-butylate in ethanol T=20°C; 1 h; 2: 2,6-Difluoroaniline in ethanol 72 h; Heating / reflux; 3: With hydrogenchloride; ammonia more than 3 stages;
1.1: KOtBu / ethanol / 1 h / 20 °C 1.2: ethanol / 72 h / Heating 2.1: 10percent aq. NaOH / 2 h / 100 °C View Scheme
参考文献
Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anderson, Robert F.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 169 - 182
