D-alpha-氨基辛二酸合成路线 （共 13 条）
反应条件
1: t-BuOK / CH2Cl2 / 2 h / -78 °C 2: 99 percent / H2 / 10percent Pd/C / acetone / 24 h / 3040 Torr / Ambient temperature 3: 6 N HCl / bis-(2-methoxy-ethyl) ether / 48 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3676 - 3680
反应条件
hydrogenchloride Heating;
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
反应条件
1: 99 percent / H2 / 10percent Pd/C / acetone / 24 h / 3040 Torr / Ambient temperature 2: 6 N HCl / bis-(2-methoxy-ethyl) ether / 48 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3676 - 3680
反应条件
1: 99 percent / H2 / 10percent Pd/C / acetone / 24 h / 3040 Torr / Ambient temperature 2: 6 N HCl / bis-(2-methoxy-ethyl) ether / 48 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3676 - 3680
反应条件
1: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 2: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 3: 84 percent / aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7611 - 7622
反应条件
1: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 2: 84 percent / aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7611 - 7622
反应条件
1: 540 mg / aq. HCl / Heating 2: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 3: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 4: 84 percent / aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7611 - 7622
反应条件
1.1: NaI / tetrahydrofuran / Heating 2.1: NaOEt / ethanol / 0.5 h 2.2: 1.25 g / ethanol / Heating 3.1: 540 mg / aq. HCl / Heating 4.1: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 5.1: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 6.1: 84 percent / aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7611 - 7622
反应条件
1.1: NaOEt / ethanol / 0.5 h 1.2: 1.25 g / ethanol / Heating 2.1: 540 mg / aq. HCl / Heating 3.1: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 4.1: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 5.1: 84 percent / aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7611 - 7622
反应条件
hydrogenchloride in diethylene glycol dimethyl ether 48 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3676 - 3680
