2,4-二氯-5-甲氧基嘧啶合成路线 （共 7 条）
反应条件
pyridine; trichlorophosphate T=180°C; P=150.015 - 900.09 Torr; Neat (no solvent)Large scale reaction;
参考文献
Sun, Zhihua; Wang, Han; Wen, Kun; Li, Ya; Fan, Erkang
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4149 - 4153
反应条件
ammonium hydroxide in 1,4-dioxane T=100°C; 21 h; sealed tube;
参考文献
WO2011/59839 A1, ;
Page/Page column 91 ;
WO 2011/059839 A1
反应条件
water; zinc in ethanol 4 h; Reflux;
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
Location in patent: Page/Page column 27 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=75°C;
参考文献
EISAI RandD MANAGEMENT CO., LTD.
Patent: US2012/95031 A1, 2012 ;
Location in patent: Page/Page column 30-31 ;
反应条件
1: tetrahydrofuran / 5 h / 20 °C
2: ozone / dichloromethane; methanol / 5 h / -78 °C
3: sodium hydrogencarbonate; bromine / water / 5.75 h / 0 - 20 °C
View Scheme
参考文献
DOW AGROSCIENCES LLC; SIDDALL, Thomas, Lyman; ROTH, Joshua John
Patent: WO2013/102111 A1, 2013 ;
反应条件
sodium carbonate in methanol; water; toluene
参考文献
Emonds, Mark Victor Michael; Roth, Gary A.
Patent: US2002/13230 A1, 2002 ;
反应条件
sodium carbonate; hydrazine in methanol; water; toluene
T=15 - 42°C; 4.1 h;
参考文献
Dow AgroSciences LLC
Patent: US6362335 B1, 2002 ;
Location in patent: Example 2-3 ;
