1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮合成路线 （共 25 条）
反应条件
piperidine T=100 - 110°C;
参考文献
CIPLA LIMITED ET al; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; GHAGARE, Maruti Ganpati; CHIKHALIKAR, Sandip Vasant; COTTRILL, Emily Elizabeth Helen
Patent: WO2012/35303 A2, 2012 ;
Location in patent: Page/Page column 23 ;
反应条件
sodium methylate in methanol; water; toluene
参考文献
USV LIMITED; SATHE, Dhananjay, Govind; BHISE, Nandu, Baban; GATNE, Parag, Sukumar; PATNEKAR, Subodh, Shashikant; DEORE, Raviraj, Bhatu; MAHAJAN, Anil, Dinkar
Patent: WO2010/41271 A2, 2010 ;
Location in patent: Page/Page column 24 ;30 ;
反应条件
in methanol; water; toluene
参考文献
Ishida, Hajime; Fukuta, Makoto
Patent: US2004/18239 A1, 2004 ;
反应条件
1: piperidine / 100 - 110 °C 2: sodium tetrahydroborate; nickel dichloride / methanol / 15 - 25 °C 3: CHIRAL PACK IA-3 / isopropyl alcohol; diethylamine; hexane / 25 °C / Resolution of racemate View Scheme
参考文献
CIPLA LIMITED ET al; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; GHAGARE, Maruti Ganpati; CHIKHALIKAR, Sandip Vasant; COTTRILL, Emily Elizabeth Helen
Patent: WO2012/35303 A2, 2012 ;
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C 1.2: 83 percent / tetrahydrofuran / 2 h / 20 °C 2.1: 32 percent / aq. H2O2; KOH / dimethylsulfoxide; H2O / 3 h / 20 °C 3.1: H2; Ru(OAc)2[(R)-binap] / ethanol / 6 h / 50 °C / 75006 Torr 4.1: BF3*Et2O; NaBH4 / tetrahydrofuran / 24 h / 20 °C 4.2: 63 percent / aq. HCl / ethyl acetate View Scheme
参考文献
Yamano, Toru; Yamashita, Masayuki; Adachi, Mari; Tanaka, Mitsutaka; Matsumoto, Kiyoharu; Kawada, Mitsuru; Uchikawa, Osamu; Fukatsu, Kohji; Ohkawa, Shigenori
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 184 - 190
