反应条件
1.1: (R)-diphenylprolinol trimethylsilyl ether; chloroacetic acid / toluene / 6 h / 23 °C / Inert atmosphere 1.2: 2 h / 23 °C / Inert atmosphere 2.1: trifluoroacetic acid / toluene / 4 h / 23 °C / Inert atmosphere 3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 0.5 h / 23 °C / Inert atmosphere 4.1: pyridine; trimethylsilylazide / N,N-dimethyl-formamide / 20 °C / Microflow reaction; Inert atmosphere 4.2: 110 °C / Microflow reaction; Inert atmosphere 5.1: chloro-trimethyl-silane; zinc / ethanol / 2 h / 70 °C / Inert atmosphere 5.2: 0.17 h / 0 °C / Inert atmosphere 5.3: 9 h / 23 °C / Inert atmosphere View Scheme
