1.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / toluene / 2 h / 0 °C / Inert atmosphere 1.2: 5 h / 60 °C / Inert atmosphere 1.3: 20 °C / Inert atmosphere; Molecular sieve 2.1: boron trifluoride diethyl etherate / 75 °C / Inert atmosphere 3.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 1 h / 150 °C / Inert atmosphere; Microwave irradiation 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 5.1: hydrazine / ethanol / 10 h / 68 °C / Inert atmosphere View Scheme

1: sodium periodate; silica gel / dichloromethane; water / 3.58 h 2: (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; chloroacetic acid / dimethyl sulfoxide / 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 70 °C / Inert atmosphere 4: acetic acid; zinc / 34 h / 20 °C / Inert atmosphere View Scheme

1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 70 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: 4-methyl-morpholine / dichloromethane / 0 - 20 °C 3.1: dichloromethane; toluene / 2 h / 20 °C 4.1: hydrogenchloride; water / dichloromethane; toluene / 4 h / 20 °C 4.2: pH 10 View Scheme

1.1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 24 h / 20 °C / |Inert atmosphere 2.1: pyridine / dichloromethane / 1 h / -15 °C / |Inert atmosphere 3.1: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C 4.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 4.2: 4 h / 20 °C 5.1: pyridine / 2 h / 0 - 20 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere 7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 7.2: 0.75 h / -78 - 20 °C / |Inert atmosphere 8.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 8.2: 2 h / 0 °C / |Inert atmosphere 9.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 10.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 11.1: triethylamine / dichloromethane / 0.75 h / 0 °C 12.1: sodium azide / ethanol; water / 8 h / |Reflux 13.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 13.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: pyridine / dichloromethane / 1 h / -15 °C / |Inert atmosphere 2.1: sodium azide / N,N-dimethyl-formamide / 2 h / 20 °C 3.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 3.2: 4 h / 20 °C 4.1: pyridine / 2 h / 0 - 20 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere 6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 6.2: 0.75 h / -78 - 20 °C / |Inert atmosphere 7.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 7.2: 2 h / 0 °C / |Inert atmosphere 8.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 9.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 10.1: triethylamine / dichloromethane / 0.75 h / 0 °C 11.1: sodium azide / ethanol; water / 8 h / |Reflux 12.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 12.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 1.2: 4 h / 20 °C 2.1: pyridine / 2 h / 0 - 20 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere 4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 4.2: 0.75 h / -78 - 20 °C / |Inert atmosphere 5.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 5.2: 2 h / 0 °C / |Inert atmosphere 6.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 7.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 8.1: triethylamine / dichloromethane / 0.75 h / 0 °C 9.1: sodium azide / ethanol; water / 8 h / |Reflux 10.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 10.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere 2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 2.2: 0.75 h / -78 - 20 °C / |Inert atmosphere 3.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 3.2: 2 h / 0 °C / |Inert atmosphere 4.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 5.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 6.1: triethylamine / dichloromethane / 0.75 h / 0 °C 7.1: sodium azide / ethanol; water / 8 h / |Reflux 8.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 8.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 1.2: 0.75 h / -78 - 20 °C / |Inert atmosphere 2.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 2.2: 2 h / 0 °C / |Inert atmosphere 3.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 5.1: triethylamine / dichloromethane / 0.75 h / 0 °C 6.1: sodium azide / ethanol; water / 8 h / |Reflux 7.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 7.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: titanium tetrachloride / dichloromethane / 0.25 h / 0 °C / |Inert atmosphere 1.2: 2 h / 0 °C / |Inert atmosphere 2.1: 10 Pd/C; hydrogen / ethanol / 96 h / 20 °C 3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 4.1: triethylamine / dichloromethane / 0.75 h / 0 °C 5.1: sodium azide / ethanol; water / 8 h / |Reflux 6.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 6.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere 2.1: triethylamine / dichloromethane / 0.75 h / 0 °C 3.1: sodium azide / ethanol; water / 8 h / |Reflux 4.1: triphenylphosphine / tetrahydrofuran / 4 h / 20 °C 4.2: Staudinger Azide Reduction / 24 h / 20 °C View Scheme