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63148-62-9
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
奥司他韦
合成路线
（共 114 条）
651324-06-0
→
反应条件
196618-13-0
奥司他韦
反应条件
1: sodium acetate / water / 4 h / 110 - 116 °C 2: hydrogenchloride / water; ethanol / 13 - 25 °C 3: trifluoroacetic acid / 1.5 h / 50 °C 4: N,N'-dimethyl-barbituric acid; triphenylphosphine; palladium diacetate / ethanol / 2 h / 35 °C / |Sealed tube; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 1 p. 86 - 91
651324-07-1
→
反应条件
196618-13-0
奥司他韦
反应条件
1: hydrogenchloride / water; ethanol / 13 - 25 °C 2: trifluoroacetic acid / 1.5 h / 50 °C 3: N,N'-dimethyl-barbituric acid; triphenylphosphine; palladium diacetate / ethanol / 2 h / 35 °C / |Sealed tube; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 1 p. 86 - 91
757965-01-8
→
反应条件
196618-13-0
奥司他韦
反应条件
1.1: Magnesium chloride / toluene / 6 h / 25 °C 1.2: 20 h / 20 - 50 °C 2.1: methanesulfonyl chloride / toluene / 1.5 h / 5 - 10 °C 2.2: 6 h / 5 - 70 °C 3.1: benzenesulfonic Acid / 5.5 h / 120 °C 4.1: sodium acetate / water / 4 h / 110 - 116 °C 5.1: hydrogenchloride / water; ethanol / 13 - 25 °C 6.1: trifluoroacetic acid / 1.5 h / 50 °C 7.1: N,N'-dimethyl-barbituric acid; triphenylphosphine; palladium diacetate / ethanol / 2 h / 35 °C / |Sealed tube; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 1 p. 86 - 91
651324-04-8
→
反应条件
196618-13-0
奥司他韦
反应条件
1.1: methanesulfonyl chloride / toluene / 1.5 h / 5 - 10 °C 1.2: 6 h / 5 - 70 °C 2.1: benzenesulfonic Acid / 5.5 h / 120 °C 3.1: sodium acetate / water / 4 h / 110 - 116 °C 4.1: hydrogenchloride / water; ethanol / 13 - 25 °C 5.1: trifluoroacetic acid / 1.5 h / 50 °C 6.1: N,N'-dimethyl-barbituric acid; triphenylphosphine; palladium diacetate / ethanol / 2 h / 35 °C / |Sealed tube; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 8, # 1 p. 86 - 91
1132659-97-2
→
反应条件
196618-13-0
奥司他韦
反应条件
1: sulfuric acid / ethanol / 16 h / 78 °C 2: sodium carbonate / 0.5 h / 20 °C / pH 6.5 - 7 3: sodium azide / water; ethanol / 24 h / |Reflux 4: triphenylphosphine; acetic acid / water; tetrahydrofuran / 16 h / 45 °C View Scheme
参考文献
Russian Chemical Bulletin, , vol. 62, # 1 p. 163 - 170
Izv. Akad. Nauk, Ser. Khim., , vol. 62, # 1 p. 165 - 171,7
312904-11-3
→
反应条件
196618-13-0
奥司他韦
反应条件
1.1: ethanolamine; Pd/C / ethanol / 3 h / Heating 1.2: 77 percent / H2SO4 2.1: various solvent(s) 3.1: Et3N / various solvent(s) 4.1: various solvent(s) / 15 h / 111 - 112 °C / 2625.21 - 3375.27 Torr 5.1: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C 6.1: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating View Scheme
参考文献
Chimia, , vol. 58, # 9 p. 621 - 629
332047-17-3
→
反应条件
196618-13-0
奥司他韦
反应条件
1: Et3N / various solvent(s) 2: various solvent(s) / 15 h / 111 - 112 °C / 2625.21 - 3375.27 Torr 3: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C 4: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating View Scheme
参考文献
Chimia, , vol. 58, # 9 p. 621 - 629
332047-18-4
→
反应条件
196618-13-0
奥司他韦
反应条件
1: various solvent(s) / 15 h / 111 - 112 °C / 2625.21 - 3375.27 Torr 2: AcOH; MeSO3H / various solvent(s) / 15 h / 20 °C 3: NH2CH2CH2OH; Pd/C / ethanol / 3 h / Heating View Scheme
参考文献
Chimia, , vol. 58, # 9 p. 621 - 629
1041262-69-4
→
反应条件
196618-13-0
奥司他韦
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 40 °C / Inert atmosphere 2: boron trifluoride diethyl etherate / 75 °C / Inert atmosphere 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 1 h / 150 °C / Inert atmosphere; Microwave irradiation 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 5: hydrazine / ethanol / 10 h / 68 °C / Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 13 p. 3630 - 3643
1041262-65-0
→
反应条件
196618-13-0
奥司他韦
反应条件
1: boron trifluoride diethyl etherate / 75 °C / Inert atmosphere 2: pyridine; 4-(N,N-dimethlyamino)pyridine / 1 h / 150 °C / Inert atmosphere; Microwave irradiation 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 4: hydrazine / ethanol / 10 h / 68 °C / Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 13 p. 3630 - 3643
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