1-乙基-2,4-二甲氧基苯合成路线 （共 6 条）
反应条件
potassium carbonate in acetone T=50°C;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2007/21877 A1, 2007 ;
Location in patent: Page/Page column 84 ;
反应条件
ammonium formate; palladium on activated charcoal in acetic acid T=110°C; 0.333333 h;
参考文献
Ram, Siya; Spicer, Leonard D.
Tetrahedron Letters, 1988 , vol. 29, # 31 p. 3741 - 3744
反应条件
[VO(OEt)Cl2] 1.) Et2O, RT, 1 h, 2.) Et2O, RT, 2 h; Yield given. Multistep reaction;
参考文献
Ishikawa; Ogawa; Hirao
Journal of the American Chemical Society, 1998 , vol. 120, # 20 p. 5124 - 5125
反应条件
hydrogenchloride; sodium cyanoborohydride in methanol 24 h; Product distribution;
参考文献
Elliger, Carl A.
Synthetic Communications, 1985 , vol. 15, # 14 p. 1315 - 1324
参考文献
Andotra; Kumar
Journal of the Indian Chemical Society, 1990 , vol. 67, # 1 p. 76 - 77
反应条件
1: BuLi / tetrahydrofuran 2: HBr/HOAc / H2O / 1 h / 35 °C 3: 83 percent / sulphuryl chloride / CHCl3 / 4 h / Ambient temperature View Scheme
参考文献
De Paulis; Hall; Ogren; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 273 - 276
