4-(二苯基羟甲基)苯甲酸合成路线 （共 27 条）
反应条件
1: 4-bromophenylacetic acid With n-butyllithium in tetrahydrofuran; hexane T=-65°C; 0.0833333 h; 2: benzophenone in tetrahydrofuran; hexane T=-65 - 20°C; 3: With hydrogenchloride in water pH=4;
参考文献
THE GENERAL HOSPITAL CORPORATION; RAJE, Noopur; SANTO, Loredana
Patent: WO2013/13113 A2, 2013 ;
Location in patent: Page/Page column 78 ;
WO 2013/013113 A2
反应条件
1: benzophenone; p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; cyclohexane T=-65 - -10°C; 2.5 h; 2: carbon dioxide With n-butyllithium in tetrahydrofuran; cyclohexane T=-65 - 20°C;
参考文献
WO2004/52817 A1, ;
Page 16-17 ;
参考文献
Hellwinkel, Dieter; Fritsch, Helmut
Chemische Berichte, 1989 , vol. 122, p. 2351 - 2360
反应条件
potassium tert-butylate; oxygen in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Journal of the American Chemical Society, , vol. 90, p. 3800 - 3808
反应条件
1: 94 percent / p-toluenesulfonic acid / 8 h / 180 °C 2: toluene / 20 °C 3: KOH / aq. ethanol / 4 h / Heating View Scheme
参考文献
European Journal of Inorganic Chemistry, , # 9 p. 1467 - 1477
反应条件
1: toluene / 20 °C 2: KOH / aq. ethanol / 4 h / Heating View Scheme
参考文献
European Journal of Inorganic Chemistry, , # 9 p. 1467 - 1477
参考文献
Chemische Berichte, , vol. 7, p. 1208
Chemische Berichte, , vol. 11, p. 837
反应条件
1: diethyl ether 2: nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 44, p. 1627
反应条件
1: concentrated sulfuric acid 2: potassium dichromate; diluted sulfuric acid View Scheme
参考文献
Chemische Berichte, , vol. 37, p. 663
反应条件
chromium(VI) oxide; acetic acid
参考文献
Chemische Berichte, , vol. 26, p. 3081
