2-[4-(三氟甲氧基)苯基]乙醇合成路线 (共 3 条)
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 16 h; Inert atmosphere; 2: With Glauber's salt in tetrahydrofuran; diethyl ether T=70°C; 1 h;
参考文献
WO2010/81904 A1, ;
Page/Page column 51 ;
反应条件
1: 1-bromo-4-(trifluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-75°C; 0.75 h; 2: oxirane in diethyl ether; hexane T=-75°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1.1: hydrogenchloride / water; acetone 1.2: 0.02 h / Sonication 2.1: sodium tetrahydroborate / ethanol; dichloromethane / 1 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 30 p. 12466 - 12469