18-crown-6 ether; cesium fluoride in N,N-dimethyl-formamide T=100°C; 120 h;

1: 94 percent / toluene / 24 h / Heating 2: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, -78 deg C -> rt 3: 77 percent / TBAF / tetrahydrofuran / 4 h / Heating; other reagent, solvent, temperature, reaction time View Scheme

1: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) THF, -78 deg C -> rt 2: 77 percent / TBAF / tetrahydrofuran / 4 h / Heating; other reagent, solvent, temperature, reaction time View Scheme

1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=0°C; 0.5 h; 2: 2-fluoro-6-chloro benzaldehyde in tetrahydrofuran 0.5 h;

pyridine; tetrabutyl-ammonium chloride; [(t-Bu)3PH]BF4; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) in 1,4-dioxane T=170°C; 0.5 h; microwave irradiation;