5-溴甲基-3-(4-甲氧基苯基)异噁唑合成路线 （共 8 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane 1 h; Cooling with ice;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
Location in patent: Page/Page column 78 ;
反应条件
sodium hypochlorite; triethylamine in dichloromethane; water T=0 - 20°C;
参考文献
Liu, Yuxiu; Cui, Zhipeng; Liu, Bin; Cai, Baoli; Li, Yonghong; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 5 p. 2685 - 2689
反应条件
1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 1 h / 20 °C 2: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice 3: triethylamine / dichloromethane / 2 h / 20 °C 4: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice View Scheme
参考文献
Hansen, Eric C.; Levent, Mahmut; Connolly, Terrence J.
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 574 - 578
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice 2: triethylamine / dichloromethane / 2 h / 20 °C 3: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice View Scheme
参考文献
Hansen, Eric C.; Levent, Mahmut; Connolly, Terrence J.
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 574 - 578
反应条件
1: triethylamine / dichloromethane / 2 h / 20 °C 2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
反应条件
1.1: sodium ethanolate / ethanol / 8 h / 80 °C 1.2: 1.5 h / 80 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
反应条件
in ethyl acetate; toluene
参考文献
Hansen, Eric C.; Levent, Mahmut; Connolly, Terrence J.
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 574 - 578
反应条件
1: N,N-dimethyl-formamide / 5 h / 20 °C 2: hydrazine hydrate / ethanol / 5 h / Reflux View Scheme
参考文献
Liu, Yuxiu; Cui, Zhipeng; Liu, Bin; Cai, Baoli; Li, Yonghong; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 5 p. 2685 - 2689
