3,4-二甲氧基硫代苯酚合成路线 （共 12 条）
反应条件
potassium hydroxide in methanol 2 h; Reflux;
参考文献
AQUINOX PHARMACEUTICALS INC.; MACKENZIE, Lyoyd, F.; MACRURY, Thomas, B.; HARWIG, Curtis; BOGUCKI, David; RAYMOND, Jeffery, R.; PETTIGREW, Jeremy, D.; KHLEBNIKOV, Vladimir; SHAN, Rudong
Patent: WO2014/110036 A1, 2014 ;
Location in patent: Page/Page column 175 ;
反应条件
1.1: NaH / dimethylformamide 1.2: 47 percent / dimethylformamide / Heating 2.1: 100 percent / 6 h / 285 °C 3.1: 99 percent / KOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2407 - 2419
反应条件
1: 100 percent / 6 h / 285 °C 2: 99 percent / KOH / methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2407 - 2419
参考文献
Canadian Journal of Chemistry, , vol. 63, p. 2471 - 2475
反应条件
1: With potassium hydroxide in water 0.166667 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
EP1182200 A1, ;
Referential example 2 ;
反应条件
potassium hydroxide T=60°C;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
potassium carbonate in acetone
参考文献
Wolfers,H. et al.
Synthesis, 1975 , p. 43 - 44
反应条件
potassium carbonate; potassium iodide 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 1.5 h; Yield given. Multistep reaction;
参考文献
Hirota, Takashi; Tashima, Yohsuke; Sasaki, Kenji; Namba, Tetsuto; Hayakawa, Shokei
Heterocycles, 1987 , vol. 26, # 10 p. 2717 - 2725
反应条件
PPA
T=90 - 100°C; 1 h;
参考文献
Nakazumi, Hiroyuki; Kitaguchi, Tooru; Ueyama, Tamio; Kitao, Teijiro
Synthesis, 1984 , # 6 p. 518 - 520
反应条件
1: 20 percent / 75percent aq. H2SO4 / 1 h / Ambient temperature
2: 16 percent / Polyphosphoric acid / 1 h / 90 - 100 °C
View Scheme
参考文献
Nakazumi, Hiroyuki; Kitaguchi, Tooru; Ueyama, Tamio; Kitao, Teijiro
Synthesis, 1984 , # 6 p. 518 - 520
