(R)-(+)-叔丁基亚磺酰胺合成路线 （共 15 条）
反应条件
1: (-)-quinine With thionyl chloride; triethylamine T=-78 - -37°C; 1 h; 2: 1,1-dimethylethylmagnesium chloride T=-78 - 75°C; 2 h; 3: With lithium hexamethyldisilazane
参考文献
JP2005/522525 A, ;
Page/Page column 56-57 ;
反应条件
aluminum oxide; potassium fluoride; lithium hexamethyldisilazane 1.) THF, from -78 deg C to RT, overnight, 2.) THF, 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 120, # 32 p. 8011 - 8019
反应条件
lithium amide; ammonia T=-78°C;
参考文献
Organic letters, , vol. 4, # 23 p. 4025 - 4028
反应条件
TFA-d1 (trifluoroacetic acid-d1) in water-d2 0.25 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 11 p. 2109 - 2113
反应条件
lithium amide; ammonia T=-60 - 20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 76, # 13 p. 5480 - 5484
