1: methyl ethylphenylphosphonoacetate With 18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; Horner-Wadsworth-Emmons reaction; 1 h;
2: benzaldehyde in tetrahydrofuran; toluene
T=-78°C; 18 h; Title compound not separated from byproducts;
1: methyl ethyl(2,2,2-trichloroethyl)phosphonoacetate With 18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; Horner-Wadsworth-Emmons reaction; 1 h;
2: benzaldehyde in tetrahydrofuran; toluene
T=-78°C; 18 h; Title compound not separated from byproducts;
1: methyl ethyl(2,2,2-trifluoroethyl)phosphonoacetate With 18-crown-6 ether; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide in N,N-dimethyl-formamide
T=0°C; Horner-Wadsworth-Emmons reaction; 1 h;
2: benzaldehyde in N,N-dimethyl-formamide
T=0°C; 18 h; Title compound not separated from byproducts;
1: methyl ethyl(1,1,1,3,3,3-hexafluoroisopropyl)phosphonoacetate With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=-78°C; Horner-Wadsworth-Emmons reaction; 1 h;
2: benzaldehyde in tetrahydrofuran; toluene
T=-78°C; 18 h; Title compound not separated from byproducts;
