2-氟-6-(甲硫基)苯酚合成路线 （共 4 条）
反应条件
hydrogenchloride in tetrahydrofuran T=60°C; 6 h;
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
反应条件
aluminium trichloride T=100°C; 4 h;
参考文献
Morita; Kashiwagi; Nakasuji
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7464 - 7468
反应条件
1: 74 percent / pyridine, KOH / 3.5 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg c, 2.5 h, 2.) THF, hexane, RT, 24 h 3: 46 percent / aq. HCl / tetrahydrofuran / 6 h / 60 °C View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg c, 2.5 h, 2.) THF, hexane, RT, 24 h 2: 46 percent / aq. HCl / tetrahydrofuran / 6 h / 60 °C View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
