4-二甲胺基丁醛缩二甲醇合成路线 （共 14 条）
反应条件
hydrogenchloride in N,N-dimethyl-formamide T=80 - 85°C; Product distribution / selectivity;
参考文献
WO2006/53116 A2, ;
Page/Page column 12 ;
反应条件
sulfuric acid 2 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1799 - 1810
反应条件
sulfuric acid 2 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3738 - 3741
反应条件
1: With hydrogenchloride in water T=25 - 90°C; pH=2 - 9; 5 - 6 h; 2: With sodium carbonate in water pH=~ 8 - 9;
参考文献
GENERICS [UK] LIMITED
Patent: US2011/112157 A1, 2011 ;
Location in patent: Page/Page column 11 ;
