5-溴-2-(羧基甲基)苯甲酸合成路线 （共 15 条）
反应条件
1: (i), (ii) SOCl2, (iii) /BRN= 102415/, Et2O 2: (i) MeOH, Ag2O, (ii) aq. NaOH, EtOH View Scheme
参考文献
Reichel,L.; Hampel,W.
Justus Liebigs Annalen der Chemie, 1968 , vol. 715, p. 159 - 163
反应条件
1: 76 percent / NaBH4, BF3*Et2O / tetrahydrofuran / 16 h / 25 °C 2: Et3N / CH2Cl2 / 0.5 h / below 0 deg C 3: NH3 / tetrahydrofuran / 60 h / -78 - 24 °C / 6205.8 Torr View Scheme
参考文献
Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119
反应条件
1.1: thionyl chloride / dichloromethane / 12 h / Reflux 2.1: 2 h / Reflux 3.1: triethylamine / tetrahydrofuran / 0.5 h / -5 °C 3.2: 0.5 h / -5 °C 4.1: sodium azide / tetrahydrofuran; water / -5 °C 5.1: benzene / Reflux 6.1: dichloromethane / 2 h / 20 °C 7.1: potassium carbonate / acetonitrile / 60 °C View Scheme
参考文献
Kilikli, Alper A.; Dengiz, Cagatay; Oezcan, Sevil; Balci, Metin
Synthesis, 2011 , # 22 art. no. T71611SS, p. 3697 - 3705
反应条件
thionyl chloride in dichloromethane
Reflux;
参考文献
Ozcan, Sevil; Dengiz, Cagatay; Delioemeroglu, Murat K.; Sahin, Ertan; Balci, Metin
Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1495 - 1497
反应条件
in acetone
T=20°C; 18 h;
参考文献
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD; Connon, Stephen J.; Tallon, Sean; Cornaggia, Claudio; Manoni, Francesco; Torrente, Esther
Patent: US2013/245268 A1, 2013 ;
Location in patent: Page/Page column ;
