potassium hydroxide in acetone 2 h; Heating;

1.1: LDA / tetrahydrofuran / 0.05 h / -90 °C 1.2: 99 percent / HMPA / tetrahydrofuran / 1 h / -90 - 20 °C 2.1: (R)-1,1'-bi-2-naphthol; SnCl4 / toluene / -90 - 20 °C 2.2: LiOH; aq. H2O2 / ethanol / 0.5 h / 50 - 55 °C View Scheme