5-甲基-2-苯基-1,2-二氢吡唑-3-酮合成路线 （共 111 条）
反应条件
1: 92 percent / N,N-diisopropylethylamine / CH2Cl2 / Heating
2: 76 percent / anhydrous K3PO4; dppf / PdCl2(dppf) / dioxane / 16 h / 100 °C
View Scheme
参考文献
Dvorak, Curt A.; Rudolph, Dale A.; Ma, Sandy; Carruthers, Nicholas I.
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 4188 - 4190
反应条件
1: 3-methyl-1-phenyl-3-pyrazolin-5-one With calcium hydroxide powder in 1,4-dioxane
T=50°C; 0.333333 h;
2: benzyl chloroformate in 1,4-dioxane
T=10 - 90°C; 3 h;
参考文献
AMGEN INC.
Patent: WO2008/86014 A2, 2008 ;
Location in patent: Page/Page column 55 ;
反应条件
T=110 - 115°C; P=22065.2 Torr; Hydrogenation.anschliessend Umsetzung mit Dimethylsulfat;
参考文献
Riedel-de Haen
Patent: DE962254 , 1954 ;
反应条件
ammonium cerium(IV) nitrate; nitric acid in water
T=25°C; 0.333333 h; Yield given;
参考文献
Chauhan, R. P. S.; Dwivedi, R. K.; Singh, A. L.; Shukla, I. C.
Journal of the Indian Chemical Society, 1981 , vol. 58, p. 719 - 720
参考文献
Tanaka, Tomoo; Tanaka, Kuniyuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 445 - 450
反应条件
methanol; nickel
T=100 - 115°C; P=22065.2 Torr; Hydrogenation;
参考文献
Buechi et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 670,674
Full Text Show Details
Riedelde Haen
Patent: DE962254 , 1954 ;
参考文献
Eastman Kodak Co.
Patent: US2694703 , 1952 ;
参考文献
Eastman Kodak Co.
Patent: US2694703 , 1952 ;
参考文献
Guthrie, Daryl A.; Kim, Nam Y.; Siegler, Maxime A.; Moore, Cathy D.; Toscano, John P.
Journal of the American Chemical Society, 2012 , vol. 134, # 4 p. 1962 - 1965
参考文献
Perroncito
Gazzetta Chimica Italiana, 1935 , vol. 65, p. 1254,1256
