6-(4-硝基苯甲酰)-1,3-苯并二氧戊环-5-乙酸甲酯合成路线 （共 5 条）
反应条件
phosphorus pentoxide in 1,2-dichloro-ethane 28 h; Heating;
参考文献
Euro-Celtique S.A.
Patent: EP1021418 B1, 2004 ;
Location in patent: Page 11; 17 ;
反应条件
phosphorus pentoxide in 1,2-dichloro-ethane T=20°C; Friedel-Crafts acylation; 12 h;
参考文献
Micale, Nicola; Zappala, Maria; Grasso, Silvana
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 853 - 859
反应条件
in ClCH2 CH2 Cl; water
参考文献
US5891871 A1, ;
US 5891871 A
反应条件
1: 94 percent / aq. HCl / dioxane / 1 h / Heating 2: 68 percent / H2 / 10 percent Pd/C / methanol / 4 h / 20 °C / atmospheric pressure 3: 65 percent / P2O5 / 1,2-dichloro-ethane / 12 h / 20 °C View Scheme
参考文献
Farmaco (Societa chimica italiana : 1989), , vol. 57, # 10 p. 853 - 859
反应条件
1: 86 percent / conc. H2SO4 / 48 h / Heating 2: 50 percent / P2O5 / 1,2-dichloro-ethane / 28 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 14 p. 2621 - 2625
