1-(3 -羟丙基)吡咯烷合成路线 （共 16 条）
反应条件
hydrogenchloride; sodium hydroxide; dihydrogen peroxide 1. aq. acetone, reflux, 15 min; 2. aq. THF, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 8 p. 2150 - 2156
反应条件
thionyl chloride in dichloromethane 2.5 h; cooling;
参考文献
Le Sann, Christine; Baron, Anne; Mann, John; Van Den Berg, Hendrik; Gunaratnam, Mekala; Neidle, Stephen
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 7 p. 1305 - 1312
反应条件
thionyl chloride in dichloromethane T=20°C; 2 h;
参考文献
Le Sann, Christine; Huddleston, Jonathan; Mann, John
Tetrahedron, 2007 , vol. 63, # 52 p. 12903 - 12911
反应条件
hydrogen bromide in toluene
参考文献
Hashimoto, Noriaki; Sagara, Yufu; Asai, Masanori; Nishimura, Teruyuki
Patent: US2008/90799 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20°C; Mitsunobu reaction; Inert atmosphere;
参考文献
Liu, Feng; Barsyte-Lovejoy, Dalia; Allali-Hassani, Abdellah; He, Yunlong; Herold, J. Martin; Chen, Xin; Yates, Christopher M.; Frye, Stephen V.; Brown, Peter J.; Huang, Jing; Vedadi, Masoud; Arrowsmith, Cheryl H.; Jin, Jian
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 6139 - 6150
反应条件
1: 3-(pyrrolidin-1-yl)propan-1-ol With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0°C; 0.166667 h;
2: 4-fluoro-nitro-benzene in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1852423 A1, 2007 ;
Location in patent: Page/Page column 6; 14 ;
EP 1852423 A1
